Department of Normal Physiology of the Avicenna Tajik State Medical University

Aim. To study the relationship between selected laboratory criteria characterizing genetic features, hormonal and immune sta- tus, signs of antiphospholipid reaction for assessing and predicting the reproductive health of women.

Material and methods. 85 women were observed: 28 – control group, previous pregnancies ended with the birth of healthy children; 57 women had signs of reproductive health disorders (miscarriage, premature birth) in the age range from 20 to 43 years from 2010 to 2015. The frequency of occurrence of HLA class I genes and the genotyping of allelic variants of class II HLA (DRB1, DQA1, DQB1 loci), indicators of immune, hormonal and autoimmune status associated with reproductive health of women of fertile age were evaluated.

Results. By the levels of sex hormones, cortisol in the blood, state of thyroid function, presence of signs of antiphospholipid reaction based on cluster analysis, the reproductive health risk group was divided into two clusters: with deviations in the hor- monal status in the direction of lowering sex hormones, cortisol and thyroxine in the blood during growth of autoantibodies to the components of the thyroid gland; a group with a shift in the content of autoantibodies to the side of antiphospholipid reaction. This proves that violations in the risk group are heterogeneous.

Conclusion. At laboratory parameters within reference values, pathology of reproduction can be associated with changes in sev- eral groups of factors that complement each other – level of sex hormones in the blood, state of thyroid function, level of cortisol in the blood and the presence of signs of antiphospholipid reaction, what allows to estimate and predict in time the violations of reproductive health of women of fertile age on the prenosological period.

Key words: prediction, assessment of reproductive health, cluster analysis, hormonal status, immune status, antiphospholipid reaction


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Information about authors:

Khalimova Fariza Tursunbaevna – Head of the Department of Normal Physiology of the of the Avicenna  Tajik  State  Medical  University,  Doc- tor of Medical Sciences, Associate Professor; tel.: (+992)  (372)  24-45-83;  e-mail:  farizakhalimova@

Shukurov Firuz Abdufattoevich – Professor at the Department of Normal Physiology of the of the Avicenna Tajik State Medical University, Doc- tor of Medical Sciences, Professor; tel.: (+992) 907 90 38 83; e-mail:

Nurmatov Akpar Abdusattorovich – Head of the Training Division of the Khujand branch of the State Education Establishment “Institute of Post- graduate Education in Health Sphere of Republic of Tajikistan”, Professor, tel.: (+992) 918 69 36 26

Pages: 199-208

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