THE HISTOLOGICAL SPECIALITIES OF PLACENTES AND ANGIOGENESIS GROWS FACTORS EXPRESSION IN WOMEN WITH UTERUS SUTURE

KAMILOVA M.YA., KOLOBOV A.V.,

DZHURAEV A.S., YUNUSOVA S.KH.

State Establishment “Tajik Scientific-Research Institute of Obstetrics, Gynecology and Perinatology” of the Ministry of Health and Social Protection of population of the Republic of Tajikistan

Saint Petersburg State University

Avicenna Tajik State Medical University


Aim. To estimate histological features of placenta and degree of angiogenesis factors TGF–β1 и bFGF expression in woman with uterus suture.

Material and Methods. The histological and immunohistochemical studies of placenta of 10 healthy women and placenta of 12 women with suture in uterus, placentation on the front wall were conducted.

Results. The chronic placental insuffi              in women with uterus suture and placentation on the front wall more often manifests itself by hypoplastic form with circulation disorders of high degree, also light or acute form of adaptive reaction. The tendency to decreasing of bFGF expression and statistically signifi                                         increasing of TGF–β1 expression was esti- mated.

Conclusion. The pathogenesis of placental insufficiently in women with uterus suture, and placentation on the front wall characterizes with functional disorders in cells of endothelial, macrophages as results of angiogenesis factors TGF–β1 и bFGF disbalance.

Key words: uterus suture, placental insufficiently, histological features of placenta, expression angiogenesis factors TGF–β1 и bFGF


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Information about authors:

Kamilova Markhabo Yadgarovna Manager of Obstetrics Division of the State Establishment “Tajik Scientifi Institute of Obstetrics, Gynecolo- gy and Perinatology” of the Ministry of Health and Social Protection of population of the Republic of Tajikistan, Doctor of Medical Sciences; e-mail: mar- habo1958@mail.ru

Kolobov Andrey Viktorovich Head of the De- partment of Pathological Anatomy; e-mail: kolobo- chek71@mail.ru

Dzhuraev Olim Salimovich Head of the Patholo- goanatomic Division of the State Establishment “Na- tional Medical Center «Shifobakhsh»”; e-mail: alim- jouraev@mail.ru

Yunusova Surae Khursandovna Head of the De- partment of of the State Establishment “Tajik Scientif- ic-Research Institute of Obstetrics, Gynecology and Perinatology” of the Ministry of Health and Social Protection of population of the Republic of Tajikistan


Pages: 152-158

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